CLOPICO AS

INDICATIONS:

• Acute coronary syndromes (stable angina, myocardial infarction with or without ST-segment elevation)
• Coronary angioplasty
• Prevention of cardiovascular events in high-risk patients

DOSAGE:

• Clopidogrel loading dose: 300–600 mg/day
• Aspirin loading dose: 75–325 mg/day
• Maintenance dose: 75 mg/day
• Duration of treatment: optional, up to 12 months after an acute coronary syndrome in combination with acetylsalicylic acid

MECHANISM OF ACTION:

• Clopidogrel blocks the action of ADP on blood platelets, thus preventing their aggregation.
• Aspirin acts primarily by inhibiting the cyclooxygenase (COX) enzyme, which is involved in the production of prostaglandins and thromboxane A2.